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- Title
Exploring the Relationship between Liver Disease, Bacterial Translocation, and Dysbiosis: Unveiling the Gut-Liver Axis.
- Authors
Juanola, Oriol; Francés, Rubén; Caparrós, Esther
- Abstract
Background: The global burden of liver disease and cirrhosis has been progressively increasing in the last decade. The interplay between gut microbiota and immune system and the bidirectional relationship with the liver, known as the gut-liver axis, has arisen as a fundamental aspect of liver disease. Summary: Alterations of the gut microbiome have been described and include both dysbiotic microbial signatures and intestinal bacterial overgrowth. The integrity of the intestinal epithelial barrier is essential for preventing the access of harmful substances and bacterial products into the host. Bacterial translocation due to altered host-microbiota interactions triggers local immune cell activation and facilitates a chronic inflammatory state that can ultimately lead to immune exhaustion, characteristic of cirrhosis. In cirrhosis, breakdown of the gut vascular barrier allows access of bacterial products to portal blood circulation and facilitates their influx into the liver, further contributing to disease progression. Key Messages: A better understanding of the contributing factors to pathological bacterial translocation and the impact of dysbiosis in liver disease will lead to achieve innovative therapeutic strategies in cirrhosis.
- Subjects
BACTERIAL physiology; DISEASE progression; PREBIOTICS; MICROBIOLOGY; PHENOMENOLOGICAL biology; GUT microbiome; IMMUNE system; CIRRHOSIS of the liver; LIVER diseases; EPITHELIUM; CELL motility; PROBIOTICS; BLOOD circulation; FECAL microbiota transplantation; LIVER cells; BACTERIAL diseases; ANTIBIOTICS
- Publication
Visceral Medicine, 2024, Vol 40, Issue 1, p12
- ISSN
2297-4725
- Publication type
Article
- DOI
10.1159/000535962