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- Title
SEPARATION OF NON-NATURAL AMIDE AMINO ACID ENANTIOMERS BY CAPILLARY ELECTROPHORESIS WITH CM-β-CDs AS CHIRAL SELECTIVE REAGENT.
- Authors
XIAO-DAN YANG; BAO-HUI LI
- Abstract
Separation method of seven kinds of enantiomers of non-natural amide amino acid with a capillary electrophoresis (CE) was built while carboxymethyl-β-cyclodextrins (CM-β-CDs) acted as chiral selective reagent. Several different β-CD derivatives were tested for the chiral separation of non-natural amide amino acid, and it was proved that CM-β-CDs had an advantage of chiral selectivity for amide amino acids. Seven kinds of enantiomers of amide amino acids were separated by CE in a 50 μm i.d. × 60 cm (effective length 45 cm) fused-silica capillary at 20 kV. 10 mM NaH2PO4 solution was served as running buffer with 10 mM CM-β-CDs as selective reagent. The detection wavelength was set at 214 nm.
- Subjects
AMIDES; AMINO acids; ENANTIOMERS; CAPILLARY electrophoresis; CHIRALITY; CARBOXYMETHYLATION; CYCLODEXTRINS
- Publication
Oxidation Communications, 2016, Vol 39, Issue 2A, p1875
- ISSN
0209-4541
- Publication type
Article