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- Title
A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect against Salmonella Typhimurium.
- Authors
Monteiro, Guilherme Paz; Melo, Roberta Torres de; Guidotti-Takeuchi, Micaela; Dumont, Carolyne Ferreira; Ribeiro, Rosanne Aparecida Capanema; Guerra, Wendell; Ramos, Luana Munique Sousa; Paixão, Drielly Aparecida; Santos, Fernanda Aparecida Longato dos; Rodrigues, Dália dos Prazeres; Boleij, Peter; Hoepers, Patrícia Giovana; Rossi, Daise Aparecida
- Abstract
Salmonella spp. continues to figure prominently in world epidemiological registries as one of the leading causes of bacterial foodborne disease. We characterised 43 Brazilian lineages of Salmonella Typhimurium (ST) strains, characterized drug resistance patterns, tested copper (II) complex as control options, and proposed effective antimicrobial measures. The minimum inhibitory concentration was evaluated for seven antimicrobials, isolated and combined with the copper (II) complex [Cu(4-FH)(phen)(ClO4)2] (4-FH = 4-fluorophenoxyacetic acid hydrazide and phen = 1,10-phenanthroline), known as DRI-12, in planktonic and sessile ST. In parallel, 42 resistance genes were screened (PCR/microarray). All strains were multidrug resistant (MDR). Resistance to carbapenems and polymyxins (86 and 88%, respectively) have drawn attention to the emergence of the problem in Brazil, and resistance is observed also to CIP and CFT (42 and 67%, respectively), the drugs of choice in treatment. Resistance to beta-lactams was associated with the genes blaTEM/blaCTX-M in 39% of the strains. Lower concentrations of DRI-12 (62.7 mg/L, or 100 μM) controlled planktonic and sessile ST in relation to AMP/SUL/TET and AMP/SUL/TET/COL, respectively. The synergistic effect provided by DRI-12 was significant for COL/CFT and COL/AMP in planktonic and sessile ST, respectively, and represents promising alternatives for the control of MDR ST.
- Subjects
BRAZIL; SALMONELLA typhimurium; FOODBORNE diseases; ANTIBIOTICS; COPPER; BACTERIAL diseases; POLYMYXIN B
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 3, p388
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11030388