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- Title
Concentration of Penicillin G in Jawbone Affected by Antiresorptive Agent-Related Osteonecrosis Following a Single Preoperative Dose.
- Authors
Poxleitner, Philipp; Ermer, Michael Andreas; Trittler, Rainer; Feuerstein, Carolin Lena; Otten, Jörg-Elard; Schmelzeisen, Rainer; Voss, Pit Jacob; Steybe, David
- Abstract
The aim of this study was to evaluate the concentration of penicillin G in bone affected by antiresorptive agent-related osteonecrosis of the jaw (ARONJ) following a single preoperative dose of 10 million international units (6000 mg). ARONJ is a major concern in patients administered antiresorptive agents for conditions associated with pathologically increased bone resorption. Antibiotic therapy is a key component of most treatment approaches for ARONJ and penicillin based regimens, providing a cost effective therapy option with a favorable side effect profile, are administered most frequently. In this study, high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS) was applied to evaluate penicillin G concentration in serum and bone samples of 19 patients suffering from ARONJ and undergoing surgical treatment under perioperative intravenous (IV) antibiotic therapy. Penicillin G bone concentrations were above the limit of detection (0.1 μg/g bone tissue) in 16 out of 19 samples, with a median concentration of 2.7 μg/g (range 0.1–8.8 μg/g). Penicillin G concentrations in intraoperative serum samples were above the limit of detection in all serum samples, with a median concentration of 116 μg/mL (range 1–232 μg/mL). Thus, considering bacteria frequently found in ARONJ lesions, penicillin G at levels providing adequate antimicrobial activity was detected in the serum and 16 out of 19 osteonecrotic lesions of patients suffering from ARONJ.
- Subjects
PENICILLIN G; HIGH performance liquid chromatography; TANDEM mass spectrometry; OSTEONECROSIS; BONE resorption
- Publication
Antibiotics (2079-6382), 2021, Vol 10, Issue 1, p17
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics10010017