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- Title
Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis.
- Authors
Niwa, Hideki; Sasaki, Motoko; Haratake, Joji; Kasai, Takahiko; Katayanagi, Kazuyoshi; Kurumaya, Hiroshi; Masuda, Shinji; Minato, Hiroshi; Zen, You; Uchiyama, Akio; Miwa, Atsuo; Saito, Katsuhiko; Sudo, Yoshiko; Nakanuma, Yasuni
- Abstract
Aim: Serum antinuclear antibodies (ANA) are occasionally noted in patients with non-alcoholic steatohepatitis (NASH). We examined the significance of ANA in NASH. Methods: We compared clinicopathological features in patients with ANA-positive NASH ( n = 35) and ANA-negative NASH ( n = 36). Inflammatory cell profiles and the distribution of oxidative stress markers were also examined immunohistochemically. Results: ANA-positive NASH was significantly associated with female gender ( P = 0.005), high degree of portal inflammation ( P = 0.039), interface activity ( P = 0.036) and hepatocellular ballooning ( P = 0.0008). In addition, ANA of high titer (320-fold or more) was significantly associated with the histological grade and stage of NASH ( P = 0.02). The degree of steatosis wais rather mild in the high-titer ANA group( P = 0.01). The analysis of inflammatory cell profiles revealed that CD3-positive T cells were predominant and plasma cells were rather few in the portal area and hepatic lobules in both ANA-positive and ANA-negative groups. There was no difference in the distribution of oxidative stress markers between ANA-positive and ANA-negative groups. Conclusion: These findings suggest that the presence of ANA may be related to the progression of NASH and that a different type of autoimmune mechanism may be involved in the pathogenesis of NASH with ANA, compared to the pathogenesis of autoimmune hepatitis.
- Subjects
IMMUNOGLOBULINS; HEPATITIS; INFLAMMATION; OXIDATIVE stress; AUTOIMMUNE diseases
- Publication
Hepatology Research, 2007, Vol 37, Issue 11, p923
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1111/j.1872-034X.2007.00150.x