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- Title
Comparison of efficacy of four prostaglandin analogues by bilateral treatment in healthy subjects.
- Authors
Kawaguchi, Ichiro; Higashide, Tomomi; Ohkubo, Shinji; Kawaguchi, Chiaki; Sugiyama, Kazuhisa
- Abstract
Purpose: To compare the drug efficacy of four prostaglandin analogues (PGAs) by bilateral treatment in normal subjects. Methods: Three consecutive studies comparing latanoprost to three other PGAs (travoprost, tafluprost and bimatoprost) were performed in 24 healthy subjects. Each study was separated by a washout period of over 6 weeks. In each study, two drugs were randomly assigned to one eye of each subject. Study subjects instilled the assigned medication at 9:00 p.m. every day for 2 weeks. The same masked investigator measured intraocular pressure (IOP) at 9:00 a.m., 1:00 p.m. and 5:00 p.m. at baseline and repeated measurements on days 7 and 14. The differences in IOP reduction were compared between the drugs. Results: Mean diurnal IOP reduction with latanoprost on days 7 and 14 was similar to that with travoprost and tafluprost, but was significantly lower than that with bimatoprost. The association of the mean diurnal IOP reduction between latanoprost and bimatoprost on day 14 ( r = 0.25) was weak, in remarkable contrast to the strong association between latanoprost and travoprost ( r = 0.81) and between latanoprost and tafluprost (0.82). Conclusions: The short-term bilateral treatment revealed a different IOP-lowering efficacy of bimatoprost compared to other PGAs in healthy subjects.
- Subjects
PROSTAGLANDINS; BIMATOPROST; DRUG efficacy; INTRAOCULAR pressure; EYE diseases
- Publication
Japanese Journal of Ophthalmology, 2012, Vol 56, Issue 4, p346
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-012-0155-2