We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Site-directed RNA editing by harnessing ADARs: advances and challenges.
- Authors
Li, Ming; Yan, Cheng; Jiao, Yue; Xu, Yuqin; Bai, Chen; Miao, Rui; Jiang, Jiying; Liu, Jiao
- Abstract
Adenosine deaminase acting on RNA (ADAR) enzyme–mediated A-to-I RNA editing is widely distributed in the transcriptome. It plays an important role in autoimmune surveillance, tumorigenesis, and development. Recently, several site-directed RNA editing (SDRE) systems have been developed to target disease causative point mutations by flexibly exploiting the catalytic adenosine deamination properties of ADARs. This is based on the fact that A-to-I RNA editing is essentially an adenosine-guanine transition. In contrast to genome editing, RNA editing is tunable and transient, and there are still some shortcomings that need to be addressed. Here, we outline several SDRE systems that rely on the catalytic deamination activity of endogenous or exogenous ADARs, attempting to illustrate their strategies and discuss numerous shortcomings that need to be overcome in the future.
- Subjects
RNA editing; ADENOSINE deaminase; GENOME editing; CATALYTIC activity; ADENOSINES; DEAMINATION; GUANINE
- Publication
Functional & Integrative Genomics, 2022, Vol 22, Issue 6, p1089
- ISSN
1438-793X
- Publication type
Article
- DOI
10.1007/s10142-022-00910-3