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- Title
Characteristics and Drug Utilization of Patients with Hereditary Angioedema in Italy, a Real-World Analysis.
- Authors
Giacomini, Elisa; Leogrande, Melania; Perrone, Valentina; Andretta, Margherita; Bacca, Marcello; Chinellato, Alessandro; Ciaccia, Andrea; Cillo, Mariarosaria; Lombardi, Renato; Mancini, Daniela; Pagliaro, Romina; Pastorello, Maurizio; Procacci, Cataldo; Degli Esposti, Luca
- Abstract
This real-world analysis investigated the characteristics and treatment patterns of patients with hereditary angioedema (HAE) in Italy using the administrative data of health units across Italy. Patients were identified via exemption code or HAE-specific treatments (thus, all known forms, type I, II and, III, were included). The index date was that of first prescription of HAE treatments within the inclusion period (01/2010–06/2021) or of the date of exemption. The number of HAE patients included was 148 (43.2% male, mean age 43.3 years). Gastrointestinal disorders affected 36.5% patients, hypertension affected 28.4%, hypercholesterolemia affected 11.5%, and depression affected 9.5%. The frequent gastrointestinal involvement was further confirmed by the use of antiemetics and systemic antihistamines that doubled after the index date. Among patients enrolled by treatment (n = 125), n = 105 (84%) were receiving a treatment for acute attacks. This analysis provided insights into the characterization of patients with HAE and their management in Italian clinical practice, suggesting that an unmet therapeutic need could be present for such patients in terms of the clinical burden.
- Subjects
ITALY; ANGIONEUROTIC edema; GENETIC disorders; RETROSPECTIVE studies; ACQUISITION of data; ANTIHISTAMINES; TRANEXAMIC acid; MEDICAL records; DESCRIPTIVE statistics; DRUG utilization; SOCIODEMOGRAPHIC factors; DATA analysis software; DANAZOL; ANTIEMETICS
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 18, p2509
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11182509