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- Title
Sirtuin 1, but not Osteocalcin, Correlates with Lipid Accumulation Product, Visceral Adiposity and Atherogenicity Indices in Newly Diagnosed Prediabetes-Metabolic Syndrome Patients.
- Authors
Kasabri, Violet; AlBsoul-Younes, Abla; Rizik, Omar; Suyagh, Maysa; Omed, Kashma; Yassin, Govand; AlAlawi, Sundus
- Abstract
Introduction: Osteocalcin (OCN) and Sirtuin 1 (SIRT1) are intricately involved in metabolic syndrome (MetS) and prediabetes (PreDM) anomalies and derangements. In a heterogeneous pool of nondiabetic and preDM MetS recruits, adiposity, atherogenicity and blood indices, SIRT1 and OCN were compared to the respective parameters in normoglycemic and lean controls. Further testing of putative relationships between indices and markers was performed in 59 patients with MetS. Material and Methods: In this cross-sectional study, comparisons and correlations were undertaken for biomarkers, adiposity, atherogenicity and hematological indices in 29 MetS-normoglycemic and 30 newly diagnosed drug-naive MetS-preDM patients versus 29 lean, healthy and normoglycemic controls. ANOVA and Spearman rank correlations were used for statistical comparisons. Results: OCN level (OCN; ng/mL) was significantly higher in normoglycemic MetS vs. both MetS-PreDM and controls (28.13±1.22 and 26.02±3.2 vs. 23.3±3.19, P<0.001 respectively). In contrast, the circulating level of SIRT1 (ng/mL) was lower in both normoglycemic and preDM MetS vs. healthy controls (1.42±0.47 and 1.64±0.58 vs. 3.88±0.95; P<0.001, respectively). Except for fasting plasma glucose and glycated hemoglobin (A1C), no further intergroup discrepancy could be identified between normoglycemic-MetS and preDMMetS. Notably, adiposity indices and the atherogenicity index of plasma were significantly higher in both MetS (normoglycemic and preDM) groups vs. controls. The LDL-C/HDL-C ratio, visceral adiposity index, and waist/hip ratio were higher only in MetS-preDM vs. controls. In the MetS pool (n=59), OCT, but not SIRT1, was associated reciprocally with fasting glycemia and A1C, monocyte/lymphocyte ratio, but proportionally with HC. In the same MetS pool, SIRT1 correlated significantly positively with TG, lipid accumulation product, visceral adiposity index and the atherogenicity index of plasma. Conclusions: OCN and SIRT1 may reciprocally participate in the development of MetS and preDM; both biomarkers may be putatively surrogate diagnostic/prognostic tools for metabolic anomalies prediction/prevention and pharmacotherapy.
- Subjects
OSTEOCALCIN; OBESITY; DIAGNOSIS; SIRTUINS; GLYCOSYLATED hemoglobin; BLOOD sugar
- Publication
Romanian Journal of Diabetes Nutrition & Metabolic Diseases, 2020, Vol 27, Issue 3, p220
- ISSN
2068-8245
- Publication type
Article
- DOI
10.46389/rjd-2020-1034