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- Title
在有氧运动的基础上服用补肾壮骨颗粒对改善去势大鼠骨质疏松症病情的协同效果
- Authors
刘蓉; 商宇红
- Abstract
Objective To determine the efficacy and the mechanism of aerobic exercise combined with the nourishing kidney and strengthening bone granule for the treatment of postmenopausal osteoporosis ( PMOP) ,in order to provide a theoretical basis for improving the prevention and treatment of PMOP. Methods A total of 60 female rats were randomly divided into sham operation group,model group,positive control group,nourishing kidney and strengthening bone granule group,exercise group,and combined treatment group. Each group contained 10 rats. The duration of drug administration was 12 weeks. The changes of bone histomorphometry of rats in different groups were observed. The expression of bone metabolism-related protein was detected using real-time PCR. Results Compared with the sham group,the maximal loading of the left femur,the left tibia,and the structure strength of the fourth lumbar vertebra in the model group significantly decreased ( P < 0. 05) . Compared with the model group,the maximal loading of the left femur,the left tibia,and the structure strength of the fourth lumbar vertebra in the positive group,the aerobic exercise group,the nourishing kidney and strengthening bone granule group,and the combination group significantly increased ( P < 0. 05) . Compared with the model group,RANKL and OPG in the positive group,the aerobic exercise group,the nourishing kidney and strengthening bone granule group,and the combination group significantly increased ( P < 0. 05) ,while the RANKL /OPG significantly decreased ( P < 0. 05 ) . Compared with the positive group,RANKL and OPG in the combined intervention group significantly increased ( P < 0. 05) ,and RANKL /OPG significantly decreased ( P < 0. 05) . Conclusion The combination of physical exercise and the nourishing kidney and strengthening bone granule is more effective for the treatment of postmenopausal osteoporosis than exercise or the use of nourishing kidney and strengthening bone granule alone. The mechanism is through the decrease of OPG /RANKL,resulting in the inhibition of osteoclast activity.
- Subjects
OSTEOPOROSIS in women; MENOPAUSE -- Risk factors; KIDNEY physiology; AEROBIC exercises; POLYMERASE chain reaction; THERAPEUTICS
- Publication
Chinese Journal of Osteoporosis, 2017, Vol 23, Issue 6, p734
- ISSN
1006-7108
- Publication type
Article
- DOI
10.3969/j.issn.1006-7108.2017.06.007