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- Title
A Retrospective Observational Study on the Treatment Outcomes of 17 Patients with Atypical Spinal Meningioma Including Four Cases of Metastatic Meningioma.
- Authors
Kyung Hyun Kim; Jeong Yoon Park; Sung Uk Kuh; Dong Kyu Chin; Keun Su Kim; Yong Eun Cho; Sung Hyun Noh
- Abstract
Introduction: Surgical and clinical outcomes were reviewed to determine the biological behavior and prognostic factors of atypical spinal meningioma. Because of the scarcity of atypical meningioma, there is a lack of research on this type of tumor and malignant transformation. Methods: We retrospectively reviewed the data from all patients on whom we performed spinal cord tumor removal between 1994 and 2016. Seventeen patients were pathologically proved to have atypical meningioma. Surgical extent and disease progression were established by the surgeon according to operative findings, postoperative MRI, and outpatient department (OPD) follow-up. Results: Seventeen patients were included in the analysis, 12 (70%) of whom had tumors in the thoracic region, 4 (24%) of whom had tumors in the cervical region, and 1 (6%) of whom had tumors in the sacral region. Complete resection was achieved in 15 (88%) patients, and subtotal resection was performed in 2 (12%) patients. 4 (24%) patients had metastatic meningioma from brain. Among 4 patients, 3 patients administered radiotherapy after surgery as adjuvant radiotherapy. One patient who underwent surgery for anaplastic meningioma in the brain recurred, and underwent three operations in the spine. The 5- and 10-year overall survival rates were 88.3%, while the 5- and 10-year recurrence-free survival rates were 83% and 52%, respectively. Additionally the mean Ki-67 index differed significantly between patients who did and did not develop recurrence (43% vs. 14%; p = 0.001). Conclusions: Total surgical resection should be considered as a primary treatment modality for individuals with atypical spinal meningioma and if subtotal resection was performed, adjuvant radiotherapy is necessary.
- Publication
Global Spine Journal, 2018, Vol 8, p372S
- ISSN
2192-5682
- Publication type
Article
- DOI
10.1177/2192568218771072