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- Title
Reversine inhibits MMP-1 and MMP-3 expressions by suppressing of ROS/MAPK/AP-1 activation in UV-stimulated human keratinocytes and dermal fibroblasts.
- Authors
Jeong-Mi Kim; Sun young Kim; Eun-Mi Noh; Hyun-Kyung Song; Guem-San Lee; Kang-Beom Kwon; Young-Rae Lee
- Abstract
UVB has been shown to stimulate the generation of reactive oxygen species (ROS), which subsequently results in the activation of various intracellular signalling pathways and transcription factors (AP-1, NF-κB). These transcription factors are regulated by MAPKs, which increase cytokine and MMP expression. We examined the preventive effects of reversine on MMP-1 and MMP-3 expressions in NHEKs and NHDFs exposed to UVB irradiation. Also, we confirmed that reversine decreased pro-inflammatory cytokine expression in NHEKs. The mechanism underlying the MMP inhibitory effects of reversine occurred via the suppression of UVB-induced ROS generation and MAPK/AP-1 activation. Therefore, reversine is an effective therapeutic candidate for preventing skin photoageing.
- Publication
Experimental Dermatology, 2018, Vol 27, Issue 3, p298
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.13494