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- Title
Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JNK pathways in human dermal fibroblasts.
- Authors
Hwang, Bo‐Mi; Noh, Eun‐Mi; Kim, Jong‐Suk; Kim, Jeong‐Mi; You, Yong‐Ouk; Hwang, Jin‐Ki; Kwon, Kang‐Beom; Lee, Young‐Rae
- Abstract
Curcumin (diferuloylmethane) is a polyphenol derived from turmeric ( Curcuma longa), which is commonly used as a spice. Recent studies have shown that curcumin has a wide range of pharmacological activities, including anticarcinogenic, antioxidant, anti-inflammatory and antiangiogenic activities. However, the antiphotoageing effects of curcumin have yet to be characterized. In this study, we investigated the inhibitory effects of curcumin on matrix metalloproteinase ( MMP)-1 and MMP-3 expression in human dermal fibroblast cells. Western blot analysis revealed that curcumin inhibited ultraviolet ( UV) B-induced MMP-1 and MMP-3 expression. Furthermore, curcumin significantly blocked UVB-induced reactive oxygen species generation in fibroblasts. Curcumin treatment significantly blocked the UVB-induced activation of nuclear factor ( NF)-κB and activator protein ( AP)-1. Additionally, curcumin strongly repressed the UVB-induced phosphorylation of p38 and c-Jun N-terminal kinase. Curcumin prevented UVB-induced MMP expression through mitogen-activated protein kinase/ NF-κB inhibition and AP-1 activation. In conclusion, curcumin may be useful for preventing and treating skin photoageing.
- Subjects
CURCUMIN; METALLOPROTEINASES; FIBROBLASTS; TURMERIC; POLYPHENOLS; PROTEIN kinases; THERAPEUTICS
- Publication
Experimental Dermatology, 2013, Vol 22, Issue 5, p371
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12137