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- Title
Neuroglobin, an oxygen-binding protein in the mammalian nervous system (localization and putative functions).
- Authors
Alekseeva, O.; Grigor'ev, I.; Korzhevskii, D.
- Abstract
The review summarizes current data on neuroglobin, the heme-containing protein discovered in mammalian nerve cells in 2000. It presents general characteristics of neuroglobin as well as data on its evolutionary changes and expression across different taxa. Neuroglobin distribution in specific brain structures and outside the brain is described. The issue of the occurrence of neuroglobin not only in neurons but also in astroglial cells is discussed. Subcellular localization of neuroglobin is characterized with a special focus on its detection in the nucleus of nerve cells, suggesting its involvement in nuclear functions. Current ideas on the probable functional significance of neuroglobin are reported. Neuroglobin is presumed to be involved in metabolism of reactive nitrogen and oxygen species as well as in intracellular signaling pathways. Besides, neuroglobin has neuroprotective and antiapoptotic functions. Since its expression changes during ontogenesis, its neuroprotective role in ageing is specifically highlighted. Changes in expression and localization of neuroglobin are suggested to influence the adaptive potential of an organism.
- Subjects
ASTROCYTES; HEMOPROTEINS; APOPTOSIS inhibition; NERVOUS system proteins; OXYGEN metabolism
- Publication
Journal of Evolutionary Biochemistry & Physiology, 2017, Vol 53, Issue 4, p249
- ISSN
0022-0930
- Publication type
Article
- DOI
10.1134/S0022093017040019