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- Title
MOŽE LI SE TIP 1 DIJABETESA PREVENIRATI?
- Authors
STANKOVIĆ, SANDRA; VUČIĆ, JELENA; VASIĆ, KARIN; MILOJEVIĆ, DEJAN; ŽIVIĆ, SAŠA; STANKOVIĆ, TATJANA
- Abstract
Prevention of diabetes in childhood and adolescence can be conducted on three levels: primary, secondary and tertiary. Primary prevention refers to the avoidance of harmful environmental factors, especially early in life, which emphasizes the importance of paediatrics. Persons with increased risk for diabetes can be identified by HLA haplotype determination. It is necessary to insist on healthy dietary habits such as breastfeeding, avoiding of certain nutritive allergens, sufficient vitamin D supplementation, and healthy lifestyles without obesity in this group. Secondary prevention includes procedures performed when the autoimmune reaction has already been established. This can reduce the intensity of autoimmune destruction of beta cells, delaying or moderating the onset of type 1 diabetes. Autoimmunity in diabetes is recognized by characteristic autoantibodies (GAD, ICA, IA-2 or ICA 512, IAA), although it may be important to determine the glycosylated haemoglobin A1 and C-peptide. It is necessary to continue with implementation of the procedures carried in primary prevention. Tertiary prevention involves all procedures that are performed when diabetes is clinically present, with the aim of reducing the loss of insular beta cells. Although it is unambiguous that remission period in diabetes is time-limited, a further fall of the endocrine reserve to the immeasurable C-peptide level is not mandatory in all patients. There are predictive factors that can suggest a favorable disease. Among numerous immune modulation attempts in the induction of remission, in the case of "double" or "hybrid" diabetes forms medicaments, like metformin and SGLt-2 inhibitors, may be used.
- Subjects
TYPE 1 diabetes; DIABETES in children; PANCREATIC beta cells; FOOD habits; IMMUNOREGULATION; INDOLEACETIC acid; HEMOGLOBINS; AUTOANTIBODY analysis
- Publication
Paediatria Croatica, Supplement, 2019, Vol 63, p27
- ISSN
1330-724X
- Publication type
Article