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- Title
Keratinocyte expression of OKM5 antigen in inflammatory cutaneous disease.
- Authors
Barker, J.N.W.N.; Markey, A.C.; Allen, M.H.; MacDonald, D.M.
- Abstract
Keratinocyte expression of the monocyte/macrophage surface antigens defined by OKMI and OKM5 antibodies (Ortho Diagnostics) was examined using the peroxidase anti-peroxidase immunohistochcmical technique. A range of inflammatory cutaneous disorders were investigated, including lichen planus, psoriasis and atopic dermatitis. Positive suprabasal keratinocyte expression of OKM5 antigen was observed in all disorders, while keratinocyte staining with OKMI antibody was consistently negative. These results provide further evidence that keratinocytes may play an important role in cutaneous immune responses. Furthermore, they are consistent with the recent observation that HLA-DR positive keratinocytes may modulate cutaneous immunological reactions by inducing T-cell unresponsiveness.
- Subjects
ANTIGENS; KERATINOCYTES; SKIN diseases; LICHEN planus; PSORIASIS; ATOPIC dermatitis; IMMUNE response; DERMATOLOGY
- Publication
British Journal of Dermatology, 1989, Vol 120, Issue 5, p613
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1989.tb01345.x