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- Title
Lifestyle intervention improves lipoprotein particle size and distribution without weight loss in obese Latino adolescents.
- Authors
Ryder, J. R.; Vega‐López, S.; Ortega, R.; Konopken, Y.; Shaibi, G. Q.
- Abstract
Childhood obesity is associated with a pro-atherogenic phenotype contributing to increased cardiovascular disease ( CVD) risk. This single-arm pilot study examined the effects of a lifestyle intervention on lipoprotein particle size and cholesterol distribution in obese Latino adolescents. Fifteen obese Latino adolescents (15.0 ± 1.0 years) completed a 12-week nutrition education and exercise intervention. Low-density lipoprotein ( LDL) particle size and distribution of cholesterol in lipoprotein subclasses were determined via polyacrylamide gel electrophoresis. The intervention resulted in increases in mean LDL particle size (269.3 ± 3.4 to 271.6 ± 2.9 Å, P = 0.0003) and cholesterol in large high-density lipoprotein ( HDL) subfractions (22.4 ± 11.2 to 26.8 ± 10.6% area, P = 0.007) along with decreases of cholesterol in small LDL (1.6 ± 2.0 to 0.6 ± 1.2% area, P < 0.01) and HDL subfractions (23.2 ± 9.4 to 19.0 ± 6.7% area, P = 0.05). These improvements were observed independent of changes in weight (90.7 ± 26.2 to 89.9 ± 27.8 kg, P > 0.05) and suggest that lifestyle modification in obese youth may reduce cardiovascular risk by shifting lipoprotein particle size and cholesterol distribution to a less atherogenic phenotype.
- Subjects
ARTERIOSCLEROSIS prevention; OBESITY treatment; ANTHROPOMETRY; BODY weight; EXERCISE; HISPANIC Americans; LIPOPROTEINS; NUTRITION education; RESEARCH funding; PILOT projects; LIFESTYLES; DESCRIPTIVE statistics; ADOLESCENCE
- Publication
Pediatric Obesity, 2013, Vol 8, Issue 5, pe59
- ISSN
2047-6302
- Publication type
Article
- DOI
10.1111/j.2047-6310.2013.00162.x