We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Charge transfer complex-based spectrophotometric analysis of famotidine in pure and pharmaceutical dosage forms.
- Authors
Al Samarrai, Shatha Y.; AlZubaidi, Radhi; Al-Ansari, Nadhir
- Abstract
A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation reaction to determine the concentration of famotidine (FMD) in solutions. Compared to the double-distilled blank solution, the reaction result detected a definite violet colour at a maximum absorption wavelength of 546 nm, For concentrations range 2—28 µg/ml, the technique demonstrated excellent compliance with Beer-Law and Lambert's, as evidenced by its molar absorptivity of 2159.648 L mol−1 cm–1. Lower detection limits of 0.3024 µg/ml and 1.471 µg/ml, respectively, were discovered. The complexes of famotidine and Ortho-chloranil were found to have a 2:1 stoichiometry. Additionally, the suggested approach effectively estimated famotidine concentrations in pharmaceutical formulations, particularly in tablet form.
- Subjects
DOSAGE forms of drugs; CHARGE transfer; FAMOTIDINE; ELECTROPHILES; ELECTRON donor-acceptor complexes
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-54402-4