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- Title
Hepatitis C virus infection, Linxian, China.
- Authors
Zhang, Mingdong; Xiu-Di Sun; Mark, Steven D.; Chen, Wen; Wong, Lara; Dawsey, Sanford M.; You-Lin Qiao; Fraumeni Jr., Joseph F.; Taylor, Philip R.; O'Brien, Thomas R.; Sun, Xiu-Di; Qiao, You-Lin; Fraumeni, Joseph F Jr
- Abstract
Bloodborne viruses may have spread in rural China during the past 25 years, but population-based prevalence estimates are lacking. We examined the frequency of hepatitis C virus (HCV) and HIV type 1 (HIV-1) among residents of Linxian, a rural community in Henan Province. In 2000, blood was collected from participants (> or = 55 years of age) who had enrolled in a population-based nutritional intervention trial in 1985. We randomly selected 500 participants for HCV testing and 200 participants for HIV-1 testing. For HCV, 48 (9.6%) of 500 participants were positive by enzyme immunoassay and recombinant immunoblot assay (95% confidence interval, 7.0%-12.2%), and prevalence was lowest in the most geographically isolated participants. Among the HCV-infected participants, 42 had a specimen available from 1985, of which 16 (38.1%) were positive for HCV. For HIV-1, 0/200 participants were positive. We conclude that HCV is now a common infection among older adults in Linxian, China.
- Subjects
CHINA; HEPATITIS C virus; HIV; ENZYME-linked immunosorbent assay; IMMUNOBLOTTING; DISEASES in older people; HIV infection epidemiology; COMMUNICABLE disease epidemiology; VIRAL antigens; HEPATITIS B; RESEARCH; COMMUNICABLE diseases; RESEARCH methodology; HEPATITIS C; HEPATITIS viruses; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; DISEASE prevalence; RESEARCH funding; VIRAL antibodies; RURAL population; EPIDEMIOLOGICAL research
- Publication
Emerging Infectious Diseases, 2005, Vol 11, Issue 1, p17
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1101.031005