We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.
- Authors
Toralf Bernig; Brenda J. Boersma; Tiffany M. Howe; Robert Welch; Sunita Yadavalli; Brian Staats; Leah E. Mechanic; Stephen J. Chanock; Stefan Ambs
- Abstract
Common genetic variants in cancer-related genes contribute to breast cancer. The innate immune system plays a crucial role in the immune surveillance against malignancies, thus it is plausible that genetic variations in key genes of the innate immunity such as the mannose-binding lectin (MBL), MBL2, could influence the risk for breast cancer. We investigated the association of MBL2 genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26 MBL2 single nucleotide polymorphisms (SNPs) in a case–control study of breast cancer [166 African-American (AA) case patients versus 180 controls and 127 Caucasian (CAU) case patients versus 137 controls]. We observed that the A allele of the 3′-UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in AA women [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27–0.81]. Haplotype analysis of MBL2 showed that the frequency of the corresponding 3′ haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3′ STP) was lower in cases than controls among AA women (0.15 versus 0.21; P = 0.02) suggesting a protective effect after adjusting for covariates (OR = 0.51, 95% CI = 0.29–0.88, P = 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3′-UTR of MBL2 might influence the risk for breast cancer in AA women, probably in interaction with the 5′ secretor haplotypes that are associated with high concentrations of MBL.
- Subjects
LECTINS; BREAST cancer; IMMUNITY; NUCLEOTIDES
- Publication
Carcinogenesis, 2007, Vol 28, Issue 4, p828
- ISSN
0143-3334
- Publication type
Article