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- Title
Seroepidemiology of human T-cell lymphotropic virus among Iranian adult thalassemic patients.
- Authors
Keshvari, M.; Hajibeigi, B.; Azarkeivan, A.; Keyvani, H.; Behnava, B.; Saiedi Hosseini, S. Y.; Sharafi, H.; Alavian, S. M.
- Abstract
SUMMARY Background A large number of transfusion-dependent thalassemic patients is at a substantial risk for transfusion-transmitted infections. Human T-cell lymphotropic virus (HTLV) is a blood-borne pathogen and can be transmitted via cellular products. We aimed to evaluate the seroprevalence of HTLV in transfusion-dependent thalassemic patients referred to Tehran Adult Thalassemia Clinic. Methods From 2008 to 2010, 257 transfusion-dependent thalassemic patients who referred to Tehran Adult Thalassemia Clinic were enrolled. The seroprevalence of HTLV, hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV were assessed using enzyme-linked immunosorbant assay (ELISA). Also, the samples with positive result for anti-HTLVAb (by ELISA) were reassessed using Western blot for HTLV. Results Among the 257 transfusion-dependent thalassemic patients who were tested for anti-HTLVAb, 29 (11·3%, 95%CI = 7·8-15.6%) were found to be anti-HTLVAb positive by ELISA and Western blot. No case was detected to be HBsAg positive, whereas 16% had HBV seroconversion criteria, and more than 95% had anti-HBsAb in their sera. Also, 103 (40·1%) patients were HCV seropositive, 13 (5·1%) patients of which were co-infected with HCV/HTLV. Among the HTLV-infected patients, 44·8% were co-infected with HCV, whereas 39·5% of HTLV-seronegative individuals were HCV mono-infected ( P > 0·05). Conclusion This study showed that transfusion-dependent thalassemic patients were in higher risk for transmission of different blood-borne pathogens such as HTLV. The screening of HTLV in Iranian blood donors is recommended.
- Subjects
TEHRAN (Iran); HTLV diseases; THALASSEMIA; BLOOD transfusion; T-cell lymphoma; SEROPREVALENCE; BLOOD donors; PATIENTS
- Publication
Transfusion Medicine, 2014, Vol 24, Issue 4, p227
- ISSN
0958-7578
- Publication type
Article
- DOI
10.1111/tme.12133