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- Title
Synthesis of new derivatives of inositolcontaining phospholipid dimer analogs as potential inhibitors of virus adsorption.
- Authors
Baranova, E.; Dang, T.; Eremin, S.; Esipov, D.; Shastina, N.; Shvets, V.
- Abstract
The majority of known agents against human immunodeficiency virus (HIV) are targeted at the virus enzymes protease and integrase but do not prevent HIV entry into host cells. Therefore, it is critical to seek small polyanionic molecules as potential inhibitors of virus adsorption. Inositol-containing phospholipids, which are naturally occurring biologically active compounds that are involved in cell regulation, may be promising lead compounds for antiviral drug design. In the present study, dimer analogs of inositol-containing phospholipids were synthesized using the H-phosphonate method. Carboxymethyl and sulfate derivatives based on them were obtained and proposed as potential virus adsorption inhibitors.
- Subjects
VIRUS inhibitors; PHOSPHOLIPIDS; LIPID synthesis; HIV virus enzymes; DIMERS; INOSITOL; PHOSPHORYLATION; BIOACTIVE compounds
- Publication
Pharmaceutical Chemistry Journal, 2011, Vol 45, Issue 6, p344
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-011-0630-y