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- Title
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.
- Authors
Hirsch, Alec J.; Roberts, Victoria H. J.; Grigsby, Peta L.; Haese, Nicole; Schabel, Matthias C.; Xiaojie Wang; Lo, Jamie O.; Zheng Liu; Kroenke, Christopher D.; Smith, Jessica L.; Kelleher, Meredith; Broeckel, Rebecca; Kreklywich, Craig N.; Parkins, Christopher J.; Denton, Michael; Smith, Patricia; DeFilippis, Victor; Messer, William; Nelson, Jay A.; Hennebold, Jon D.
- Abstract
Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development. DOI: 10.1038/s41467-017-02499-9 OPEN 1
- Subjects
ZIKA virus infections; RHESUS monkeys; CHORIONIC villi; MACAQUES; FETAL movement; FETAL development; CENTRAL nervous system; ZIKA virus
- Publication
Nature Communications, 2018, Vol 9, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-017-02499-9