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- Title
Evaluation of Anti-nociceptive effect of Psidium guajava (L.) fruits by chemical & thermal induced models.
- Authors
Pathan, Javed Khan; Gupta, Arun Kumar
- Abstract
Psidium guajava (L.), Myrtaceae known as the poor man's apple of the tropics, has a long history of traditional use, much of which is being validated by scientific research. This aims a comprehensive of chemical constituents, pharmacological and clinical uses. Chemical constituents have been possessed useful biological activities belong mainly to phenolic, flavonoid, carotenoid, terpenoid and triterpene. The literatures show that P. guajava (L.) leaves possess antiinflammatory and anti-nociceptive activities, supports its traditional uses. In an effort to scientifically apprise some of the ethno medical properties of P. guajava (L.) fruit and probe its efficacy and safety, the present study was undertaken to examine the anti-nociceptive property of fruit hydroalcoholic extract in experimental animal paradigms "chemical & thermal induced model". The results were observed and compared by reference drug as diclofenac sodium 5mg/kg i.p., by counting wriths produced by induction of acetic acid 1% v/v, 1ml/100gm i.p. The effects observed for 10 minutes, in chemical model. Moreover, by using same reference drug, jumping response observed by induction of heat. The cut off period was 10 seconds, for thermal model. Hence results were found significant (p < 0.001) and hence showed the anti-nociceptive effect for P. guajava (L.) fruits, by chemical & thermal model.
- Subjects
GUAVA; MYRTACEAE; PHARMACOLOGY; PHENOLS; FLAVONOIDS
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 5, p57
- ISSN
0976-7126
- Publication type
Article