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- Title
A review study on the inhibitory effects of Iranian herbal medicines against in vitro replication of herpes simplex virus.
- Authors
Karimi, Ali; Alidadi, Somayeh; Moradi, Mohammad Taghi
- Abstract
Objectives: Iran has rich herbal flora with extensive ecological diversity. So far, no systematic reviews have been conducted on Iranian medicinal plants regarding their phytochemistry, bioactivity and in vitro activity against the replication of herpes simplex virus (HSV). This article aimed to review and summarize the published results on this subject as to offer recommendations for future researches. Materials and Methods: In this systematic review, we searched for articles published in English (via PubMed, ScienceDirect, EMBASE, Scopus, ProQuest, Google Scholar and Cochrane Library) and Persian (via SID, IranMedex and Magiran), from 1966 to October 2014. In-vitro studies without the measurement of CC50, IC50, or EC50 were excluded from this review. Results: Only 42 published reports were identified on the evaluation of Iranian herbs with inhibitory effects against HSV replication in vitro. In total, 17 articles were selected, in which 23 medicinal plants were subjected to crude extraction. Review of data indicated that some herbal extracts such as Hyssopus officinalis methanolic extract, Melissa officinalis aqueous extract, Quercus persica L hydro-alcoholic extract and Securigera securidaca methanol seed extract were highly effective on HSV in vitro (selective indices: 234, 877, >778 and 250, respectively). Conclusion: This systematic review covered the published results of researches on Iranian medicinal plants and the corresponding isolated active phytochemicals. According to the results, comprehensive studies with advanced methodology are required as to discover effective anti-HSV agents obtained from the bioactive compounds isolated from these medicinal plants.
- Subjects
HERBAL medicine; HERPES simplex prevention
- Publication
Avicenna Journal of Phytomedicine, 2015, Vol 5, p103
- ISSN
2228-7930
- Publication type
Article