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- Title
Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance.
- Authors
Xinghong Yao; Ye Zeng
- Abstract
Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There is a close interaction between tumour cells and endothelial cells in the tumour microenvironment. Recent studies have shown that tumour-associated endothelial cells have different characteristics from normal vascular endothelial cells, play an important role in tumour progression and metastasis, and are expected to be a key target for cancer therapy. This article reviews the tissue and cellular origin of tumour-associated endothelial cells and analyses the characteristics of tumour-associated endothelial cells. Finally, it summarises the role of tumour-associated endothelial cells in tumour progression and metastasis and the prospects for their use in clinical anti-angiogenic therapy.
- Subjects
ENDOTHELIAL cells; VASCULAR endothelial cells; NEOVASCULARIZATION inhibitors; METASTASIS; TUMOR microenvironment
- Publication
Frontiers in Physiology, 2023, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2023.1199225