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- Title
Assessment of hepatic fat content in using quantitative ultrasound measurement of hepatic/renal ratio and hepatic echo-intensity attenuation rate.
- Authors
Yun-Sheng Wang; Gui-Ping Zhang; Xiao Yang; Jun Ye; Yong-Hong Cao; Rong Zhang; Shuai Ye; Shi-Mei Xing; Er-Lan Shi; Ji Zhang; Hu Lian; Jin-Xiang Xia; Qiu Zhang; Wu Dai; Wang, Yun-Sheng; Zhang, Gui-Ping; Yang, Xiao; Ye, Jun; Cao, Yong-Hong; Zhang, Rong
- Abstract
<bold>Aims: </bold>This study aims to evaluate and validate a simple quantitative ultrasound (US) method for determining the hepatic fat content (HFC) based on the combination of quantitative US hepatic/renal ratio (US-HRR) and quantitative US hepatic echo-intensity attenuation rate (US-HAR) as compared with [1H]-magnetic resonance spectroscopy (1H-MRS).<bold>Material and Methods: </bold>There were a total of 242 subjects recruited in the present study. All subjects were examined for HFC by quantitative US and 1H-MRS methods. The QUS-HRR and QUS-HAR were calculated from ordinary ultrasound images of liver and kidney with a triple modality 3D abdominal phantom using the Image J software.<bold>Results: </bold>The results found that US-HRR and US-HAR correlated with 1H-MRS HFC (US-HRR: r=0.946, p<0.001; US-HAR: r=0.936, p<0.001). The equation for HFC prediction by using quantitative US was: HFC (%) = 28.965 × US-HRR + 218.045 × US-HAR - 8.892. Subgroup analysis in study subjects with body mass index (BMI) ≥28 showed that quantitative US HFC was associated with 1H-MRS HFC (R2=0.953, p<0.001). Receiver operating characteristic (ROC) analysis observed that the cut-off value of fatty liver diagnosis was 6.71% in using the quantitative US model; the sensitivity and specificity for fatty liver diagnosis were 94.15% and 96.30%, respectively. Variability analysis indicated that there was a relative high degree of consistency in the measurement of HFC with different operators or ultrasonic apparatus.<bold>Conclusions: </bold>Quantitative US measurement could be regarded as a simple, sensitive tool to accurately assess HFC. It provides a valid alternative to 1H-MRS as an easy, non-invasive option for the precise estimation of HFC in clinical practice.
- Subjects
RECEIVER operating characteristic curves; BODY mass index; FATTY liver; TYPE 2 diabetes; NUCLEAR magnetic resonance spectroscopy; CONTRAST-enhanced ultrasound; IMAGING phantoms; ATTENUATION (Physics); KIDNEYS; ULTRASONIC imaging; LIVER; RESEARCH funding
- Publication
Medical Ultrasonography, 2020, Vol 22, Issue 4, p393
- ISSN
1844-4172
- Publication type
journal article
- DOI
10.11152/mu-2522