We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhaled Hypertonic Saline in Infants and Young Children With Cystic Fibrosis.
- Authors
Dasenbrook, Elliott C.; Konstan, Michael W.
- Abstract
The article focuses on the use of hypertonic saline in infants and young children with cystic fibrosis. Cystic fibrosis (CF) is caused by mutation in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) protein and absence of CFTR results decrease in chloride secretion and increase in sodium absorption which causes depletion of water from the airway surface. Restoring salt and water balance in the airways of patients with CF is the main goal to of a number of therapeutic strategies. It also presents information on imaging techniques assessing lung function including Chest computed tomography and Magnetic resonance imaging.
- Subjects
PHYSIOLOGIC salines; CYSTIC fibrosis treatment; PROTEINS; SODIUM chlorate; CELLULAR signal transduction; RESPIRATION; TOMOGRAPHY; MAGNETIC resonance imaging; THERAPEUTICS
- Publication
JAMA: Journal of the American Medical Association, 2012, Vol 307, Issue 21, p2316
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2012.5853