We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Acute Insulin-Induced Hypoglycemia on Spatial Abilities in Adults With Type 1 Diabetes.
- Authors
Wright, Rohana J.; Frier, Brian M.; Deary, Ian J.
- Abstract
OBJECTIVE-- To examine the effects of acute insulin-induced hypoglycemia on spatial cognitive abilities in adult humans with type 1 diabetes. RESEARCH DESIGN AND METHODS-- Sixteen adults with type 1 diabetes underwent two counterbalanced experimental sessions: euglycemia (blood glucose 4.5 mmol/l [81 mg/dl]) and hypoglycemia (2.5 mmol/l [45 mg/dl]). Arterialized blood glucose levels were maintained using a hyperinsulinemic glucose clamp technique. During each session, subjects underwent detailed assessment of spatial abilities from the Kit of Factor-Referenced Cognitive Tests and two tests of general cognitive function. RESULTS -- Spatial ability performance deteriorated significantly during hypoglycemia. Results for the Hidden Patterns, Card Rotations, Paper Folding, and Maze Tracing tests were all impaired significantly (P ≤ 0.001) during hypoglycemia, as were results for the Cube Comparisons Test (P = 0.03). The Map Memory Test was not significantly affected by hypoglycemia. CONCLUSIONS -- Hypoglycemia is a common side effect of insulin therapy in individuals with type 1 diabetes, and spatial abilities are of critical importance in day-to-day functioning. The deterioration in spatial abilities observed during modest experimental hypoglycemia provides novel information on the cerebral hazards of hypoglycemia that has potential relevance to everyday activities.
- Subjects
INSULIN shock; HYPOGLYCEMIA; INSULIN; SPATIAL ability; DRUG side effects; PEOPLE with diabetes
- Publication
Diabetes Care, 2009, Vol 32, Issue 8, p1503
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc09-0212