We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinctive subgingival microbial signatures in older adults with different levels of cognitive function.
- Authors
Chen, Lili; Li, Xiuli; Liu, Jinxiu; Hou, Zhaoyi; Wei, Yongbao; Chen, Mingfeng; Wang, Bixia; Cao, Huizhen; Qiu, Rongyan; Zhang, Yuping; Ji, Xinli; Zhang, Ping; Xue, Mianxiang; Qiu, Linlin; Wang, Linlin; Li, Hong
- Abstract
Aim: To examine association between subgingival microbial signatures and levels of cognitive impairment in older adults. Materials and Methods: We analysed subgingival plaque samples and 16S ribosomal RNA sequences for microbiota among 165 participants (normal controls [NCs]: 40, subjective cognitive decline [SCD]: 40, mild cognitive impairment [MCI]: 49 and dementia: 36). Results: The bacterial richness was lower among individuals with worse cognitive function, and subgingival microbial communities differed significantly among the four groups. Declining cognitive function was associated with decreasing relative abundance of genera Capnocytophaga, Saccharibacteria_genera_incertae_sedis, Lautropia and Granulicatella, and increasing abundance of genus Porphyromonas. Moreover, there were differentially abundant genera among the groups. Random forest model based on subgingival microbiota could distinguish between cognitive impairment and NC (AUC = 0.933, 95% confidence interval 0.873–0.992). Significant correlations were observed between oral microbiota and sex, Montreal Cognitive Assessment (MoCA) score and Mini‐Mental State Examination score. Partial correlation analysis showed that Leptotrichia and Burkholderia were closely negatively associated with the MoCA score after adjusting for multiple covariates. Gene function was not significantly different between SCD and NC groups, whereas three homozygous genes were altered in MCI patients and two in dementia patients. Conclusions: This is the first study to demonstrate an association between the composition, function and metabolic pathways of subgingival microbiota and different levels of cognitive function among older individuals. Future cohort studies should assess its diagnostic usefulness for cognitive impairment.
- Subjects
COGNITION disorder risk factors; RISK assessment; RESEARCH funding; GINGIVA; DESCRIPTIVE statistics; BURKHOLDERIA; RNA; CONFIDENCE intervals; GRAM-negative anaerobic bacteria; SEQUENCE analysis; GRAM-negative bacteria; OLD age
- Publication
Journal of Clinical Periodontology, 2024, Vol 51, Issue 8, p1066
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13997