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- Title
Adjunctive benefits of systemic metronidazole on non‐surgical treatment of peri‐implantitis. A randomized placebo‐controlled clinical trial.
- Authors
Blanco, Carlota; Pico, Alex; Dopico, Jose; Gándara, Pilar; Blanco, Juan; Liñares, Antonio
- Abstract
Aim: To study clinical, radiographic, and microbiological outcomes after non‐surgical therapy of peri‐implantitis with or without adjunctive systemic metronidazole. Materials and Methods: A randomized placebo‐controlled clinical trial was carried out in 32 subjects (62 implants) diagnosed with peri‐implantitis. Implants received a mechanical non‐surgical debridement session and systemic metronidazole or placebo. Clinical, radiographic, and microbiological outcomes were evaluated at baseline, 3, 6, and 12 months. Results: After 12 months, the test treatment resulted in significantly greater PPD reduction (2.53 vs. 1.02 mm) and CAL gain (2.14 vs. 0.53 mm) (p value <.05) in comparison with placebo. The test treatment also resulted in additional radiographic bone gain (2.33 vs. 1.13 mm) compared with placebo (p value <.05). There was a significantly greater decrease in Porphyromonas gingivalis, Tannerella forsythia, and Campylobacter rectus counts compared with the control group (p value <.05). At the end of follow‐up, 56.3% of patients met the success criteria in the test group and 25% in the control group. Conclusions: The use of systemic metronidazole as an adjunct to non‐surgical treatment of peri‐implantitis resulted in significant additional improvements in clinical, radiographic, and microbiological parameters after 12 months of follow‐up. This study is registered in ClinicalTrials.gov (NCT03564301).
- Subjects
METRONIDAZOLE; PLACEBOS; PERI-implantitis; RANDOMIZED controlled trials; DEBRIDEMENT; BLIND experiment; LONGITUDINAL method
- Publication
Journal of Clinical Periodontology, 2022, Vol 49, Issue 1, p15
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13564