We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
- Authors
Feres, Magda; Soares, Geisla Mary Silva; Mendes, Juliana Alethusa Velloso; Silva, Maike Paulino; Faveri, Marcelo; Teles, Ricardo; Socransky, Sigmund S.; Figueiredo, Luciene Cristina
- Abstract
Aim To evaluate the effects of the adjunctive use of metronidazole ( MTZ) or MTZ + amoxicillin ( AMX) in the treatment of generalized chronic periodontitis (ChP). A secondary aim was to examine a possible added effect of chlorhexidine to these therapies. Methods One hundred and eighteen subjects received scaling and root planing ( SRP) only or with MTZ [400 mg/thrice a day ( TID)] or MTZ+ AMX (500 mg/ TID) for 14 days. Half of the subjects in each group rinsed with 0.12% chlorhexidine twice a day (BID) for 2 months. Subjects were clinically monitored at baseline, 3, 6 and 12-months post-therapy. Results The two antibiotic groups showed lower mean number of sites with probing depth ( PD) ≥5 mm and fewer subjects exhibiting ≥9 of these sites at 1-year post-treatment. Logistic regression analysis showed that antibiotics were the only significant predictors of subjects presenting ≤4 sites with PD ≥5 mm at 1 year ( MTZ+ AMX: OR, 13.33; 95% CI, 3.75-47.39/ p = 0.0000; MTZ: OR, 7.26; 95% CI, 2.26-23.30/ p = 0.0004). The frequency of adverse events did not differ between the two antibiotic treatments ( p > 0.05). The chlorhexidine subgroups showed a trend ( p > 0.05) to present fewer residual sites ≥5 mm compared with the placebo subgroups at 1 year. Conclusion Treatment of generalized ChP is significantly improved by the adjunctive use of MTZ+ AMX and MTZ.
- Subjects
BRAZIL; AMOXICILLIN; ANALYSIS of variance; COMBINATION drug therapy; CHI-squared test; CONFIDENCE intervals; DENTAL scaling; EPIDEMIOLOGY; METRONIDAZOLE; PERIODONTITIS; PLACEBOS; REGRESSION analysis; RESEARCH funding; STATISTICS; TOOTH root planing; LOGISTIC regression analysis; DATA analysis; RANDOMIZED controlled trials; BLIND experiment; DESCRIPTIVE statistics
- Publication
Journal of Clinical Periodontology, 2012, Vol 39, Issue 12, p1149
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12004