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- Title
No association between the ryanodine receptor 3 gene and autism in a Japanese population.
- Authors
Tochigi, Mamoru; Kato, Chieko; Ohashi, Jun; Koishi, Shinko; Kawakubo, Yuki; Yamamoto, Kenji; Matsumoto, Hideo; Hashimoto, Ohiko; Kim, Soo‐Yung; Watanabe, Keiichiro; Kano, Yukiko; Nanba, Eiji; Kato, Nobumasa; Sasaki, Tsukasa
- Abstract
Aim: Autism is a neurodevelopmental disorder with a complex genetic etiology. Chromosome 15q11-q14 has been proposed to harbor a gene for autism susceptibility because deletion of the region leads to Prader-Willi syndrome or Angelman syndrome, having phenotypic overlap with autism. Here we studied the association between autism and the ryanodine receptor 3 (RyR3) gene, which is located in the region. This is the first study, to our knowledge, that has investigated the association. Methods: We genotyped 14 tag single nucleotide polymorphisms (SNPs) in 166 Japanese patients with autism and 375 controls. Results: No significant difference was observed between the patients and controls in allelic frequencies or genotypic distributions of the 14 SNPs. Analysis after confining the subjects to males showed similar results. Conclusions: The present study provides no positive evidence for the association between the RyR3 gene and autism in the Japanese population.
- Subjects
TREATMENT of autism; RYANODINE receptors; GENETIC polymorphisms; PRADER-Willi syndrome; HUMAN chromosome 15 abnormalities; SCIENTIFIC method
- Publication
Psychiatry & Clinical Neurosciences, 2008, Vol 62, Issue 3, p341
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1111/j.1440-1819.2008.01802.x