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- Title
Association analysis of the 5-HT<sub>6</sub> receptor polymorphism C267T with depression in patients with Alzheimer's disease.
- Authors
Liu, Hsiu-Chih; Hong, Chen-Jee; Liu, Chia-Yih; Lin, Ker-Neng; Tsai, Shih-Jen; Liu, Tsung-Yun; Chi, Chin-Wen; Wang, Pei-Ning
- Abstract
Abstract A significant increase of 267C allele of the 5-HT6 receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers for evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT6 genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant.
- Subjects
ALZHEIMER'S disease; MENTAL depression; GENETIC polymorphisms; SEROTONIN
- Publication
Psychiatry & Clinical Neurosciences, 2001, Vol 55, Issue 4, p427
- ISSN
1323-1316
- Publication type
Article
- DOI
10.1046/j.1440-1819.2001.00886.x