We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Determinants of severity among hospitalised COVID-19 patients: Hospital-based case-control study, India, 2020.
- Authors
Zodpey, Sanjay P.; Negandhi, Himanshu; Kamal, Vineet Kumar; Bhatnagar, Tarun; Ganeshkumar, Parasuraman; Athavale, Arvind; Kadri, Amiruddin; Patel, Amit; Bhagyalaxmi, A.; Khismatrao, Deepak; Theranirajan, E.; Banumathi, Getrude; Singh, Krishna; Parameshwari, P.; Kshirsagar, Prasita; Saxena, Rita; Deshpande, Sanjay G.; Satyanand, Kadloor; Hadke, Saurabh; Dube, Simmi
- Abstract
Background: Risk factors for the development of severe COVID-19 disease and death have been widely reported across several studies. Knowledge about the determinants of severe disease and mortality in the Indian context can guide early clinical management. Methods: We conducted a hospital-based case control study across nine sites in India to identify the determinants of severe and critical COVID-19 disease. Findings: We identified age above 60 years, duration before admission >5 days, chronic kidney disease, leucocytosis, prothrombin time > 14 sec, serum ferritin >250 ng/mL, d-dimer >0.5 ng/mL, pro-calcitonin >0.15 μg/L, fibrin degradation products >5 μg/mL, C-reactive protein >5 mg/L, lactate dehydrogenase >150 U/L, interleukin-6 >25 pg/mL, NLR ≥3, and deranged liver function, renal function and serum electrolytes as significant factors associated with severe COVID-19 disease. Interpretation: We have identified a set of parameters that can help in characterising severe COVID-19 cases in India. These parameters are part of routinely available investigations within Indian hospital settings, both public and private. Study findings have the potential to inform clinical management protocols and identify patients at high risk of severe outcomes at an early stage.
- Subjects
INDIA; COVID-19; FIBRIN fibrinogen degradation products; COVID-19 pandemic; CASE-control method; CHRONIC kidney failure; FERRITIN
- Publication
PLoS ONE, 2021, Vol 16, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0261529