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- Title
Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial.
- Authors
Lê, Minh Patrick; Peiffer-Smadja, Nathan; Guedj, Jeremie; Néant, Nadège; Mentré, France; Ader, Florence; Yazdanpanah, Yazdan; Peytavin, Gilles
- Abstract
Around the world, several dose regimens of hydroxychloroquine have been used for COVID-19 infection treatment, with the objective of identifying a short-term course. Hydroxychloroquine was found to decrease the viral replication in a concentration-dependent manner in vitro and to be more active when added prior to the viral challenge. A loading dose is used to rapidly attain a target drug concentration, which is usually considered as approximately the steady-state concentration. With a loading dose, the minimum effective concentration is reached much more rapidly than when using only the maintenance dose from the start. Thus, we propose a hydroxychloroquine sulphate dose regimen of 400 mg twice daily at Day 1 then 400 mg once daily from Day 2 to Day 10. We aim to evaluate this in the C-20-15 DisCoVeRy trial.
- Subjects
VIRAL pneumonia; RESEARCH; CLINICAL trials; RESEARCH methodology; COVID-19; EVALUATION research; MEDICAL cooperation; DRUG administration; COMPARATIVE studies; EPIDEMICS; HYDROXYCHLOROQUINE
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2020, Vol 75, Issue 9, p2376
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkaa191