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- Title
Antimycotic potential of a diterpenoid taxoquinone against Candida species isolated from Metasequoia glyptostroboides.
- Authors
Bajpai, Vivek K.; Sun Chul Kang
- Abstract
The objective of this study was to confirm the antimycotic potential of a diterpenoid compound taxoquinone, isolated from Metasequoia glyptostroboides against pathogenic isolates of Candida species. The taxoquinone (100 µg/disc) displayed potential anticandidal effect against Candia albicans KBN06P00076, KBN06P00074, C. glabrata KBN06P00066, KBN06P00068, C. tropicalis KBN06P00682, KBN06P00058, C. parapsilosis KBN06P00060, KBN06P00055, and C. guilliermondii KBN06P00492 and KBN06P00867 as a diameter of zones of inhibition, found in the range of 10 ± 0.6 to 13 ± 1.1 mm. The minimum inhibitory and minimum fungicidal concentrations of taxoquinone against the tested clinical isolates were found in the range of 125 to 500 and 125 to 1,000 µg/mL, respectively. On the viable counts of the tested fungal isolates, the taxoquinone evoked a remarkable anticandidal effect. Elaborative study of SEM revealed potential detrimental effect of taxoquinone on the morphology of C. parapsilosis KBN06P00060 at MIC concentration. These findings confirmed therapeutic potential of taxoquinone.
- Subjects
DAWN redwood; ANTIFUNGAL agents; CANDIDA; DITERPENES; SCANNING electron microscopes; SACCHAROMYCETACEAE
- Publication
Bangladesh Journal of Pharmacology, 2014, Vol 9, Issue 2, p154
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v9i2.17555