We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy and safety of 3 day versus 7 day cefditoren pivoxil regimens for acute uncomplicated cystitis: multicentre, randomized, open-label trial.
- Authors
Takuya Sadahira; Koichiro Wada; Motoo Araki; Ayano Ishii; Atsushi Takamoto; Yasuyuki Kobayashi; Masami Watanabe; Toyohiko Watanabe; Yasutomo Nasu; Hiromi Kumon; Sadahira, Takuya; Wada, Koichiro; Araki, Motoo; Ishii, Ayano; Takamoto, Atsushi; Kobayashi, Yasuyuki; Watanabe, Masami; Watanabe, Toyohiko; Nasu, Yasutomo; Kumon, Hiromi
- Abstract
<bold>Background: </bold>Fluoroquinolone-non-susceptible Escherichia coli isolated from patients with acute uncomplicated cystitis are a matter of increasing concern. Cefditoren pivoxil is an oral, β-lactamase-stable, extended-spectrum cephalosporin that is effective against fluoroquinolone-non-susceptible bacteria.<bold>Objectives: </bold>To evaluate the clinical and microbiological efficacies of cefditoren pivoxil against acute uncomplicated cystitis and to determine the optimal duration of cefditoren pivoxil treatment.<bold>Methods: </bold>We compared 3 and 7 day regimens of cefditoren pivoxil in a multicentre, randomized, open-label study.<bold>Results: </bold>A total of 104 female patients with acute uncomplicated cystitis were enrolled and randomized into 3 day (n = 51) or 7 day (n = 53) treatment groups. At first visit, 94 bacterial strains were isolated from the 104 participants of which 81.7% (85/104) were E. coli. Clinical and microbiological efficacies were evaluated 5-9 days following administration of the final dose of cefditoren pivoxil. The clinical efficacies of the 3 and 7 day groups were 90.9% (40/44) and 93.2% (41/44), respectively (P = 1.000). The microbiological efficacies of the 3 and 7 day groups were 82.5% (33/40) and 90.2% (37/41), respectively (P = 0.349). There were no adverse events due to cefditoren pivoxil treatment, with the exception of a mild allergic reaction in one patient, after which the cefditoren pivoxil was exchanged for another antimicrobial.<bold>Conclusions: </bold>Cefditoren pivoxil is safe and effective for uncomplicated cystitis, with no significant differences in clinical and microbiological efficacies between 3 and 7 day regimens.
- Subjects
CEPHALOSPORINS; DRUG efficacy; CYSTITIS; ANTI-infective agents; FLUOROQUINOLONES; THERAPEUTICS; ANTIBIOTICS; COMPARATIVE studies; DRUG resistance in microorganisms; ENTEROCOCCUS; ESCHERICHIA coli; ESCHERICHIA coli diseases; KLEBSIELLA; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; QUINOLONE antibacterial agents; RESEARCH; STAPHYLOCOCCUS; EVALUATION research; RANDOMIZED controlled trials; CITROBACTER; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2017, Vol 72, Issue 2, p529
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkw424