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- Title
Shank2 Deletion in Parvalbumin Neurons Leads to Moderate Hyperactivity, Enhanced Self-Grooming and Suppressed Seizure Susceptibility in Mice.
- Authors
Lee, Seungjoon; Lee, Eunee; Kim, Ryunhee; Kim, Jihye; Lee, Suho; Park, Haram; Yang, Esther; Kim, Hyun; Kim, Eunjoon
- Abstract
Shank2 is an abundant postsynaptic scaffolding protein implicated in neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD). Deletion of <italic>Shank2</italic> in mice has been shown to induce social deficits, repetitive behaviors, and hyperactivity, but the identity of the cell types that contribute to these phenotypes has remained unclear. Here, we report a conditional mouse line with a <italic>Shank2</italic> deletion restricted to parvalbumin (PV)-positive neurons (<italic>Pv-Cre;Shank2</italic>fl/fl mice). These mice display moderate hyperactivity in both novel and familiar environments and enhanced self-grooming in novel, but not familiar, environments. In contrast, they showed normal levels of social interaction, anxiety-like behavior, and learning and memory. Basal brain rhythms in <italic>Pv-Cre;Shank2</italic>fl/fl mice, measured by electroencephalography, were normal, but susceptibility to pentylenetetrazole (PTZ)-induced seizures was decreased. These results suggest that <italic>Shank2</italic> deletion in PV-positive neurons leads to hyperactivity, enhanced self-grooming and suppressed brain excitation.
- Subjects
SPASMS; PARVALBUMINS; NEURONS
- Publication
Frontiers in Molecular Neuroscience, 2018, pN.PAG
- ISSN
1662-5099
- Publication type
Article
- DOI
10.3389/fnmol.2018.00209