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- Title
Childhood‐Onset Cluster Headache: Observations From a Personal Case‐Series and Review of the Literature.
- Authors
Taga, Arens; Russo, Marco; Paglia, Maria Vittoria; Torelli, Paola; Manzoni, Gian Camillo
- Abstract
Background/Objectives: Puberty seems to be a turning point in cluster headache (CH) onset. To verify its influence on CH phenotype, we focused on cases with onset ≤13 years. A review of the literature follows. Method: We considered CH cases with age‐of‐onset ≤13 years evaluated at our center between 1975 and 2015; these cases were matched by sex to two consecutive patients with age‐of‐onset as close as possible (±2 years) to the median age‐of‐onset of the overall CH population. Results: Of the overall 808 cases (585 men and 223 women, <italic>M</italic>:<italic>F</italic> ratio = 2.6), 38 patients (20 men and 18 women, <italic>M</italic>:<italic>F</italic> ratio = 1.1) had pediatric onset (PO). The diagnostic delay was significantly higher among cases with PO (21.2 ± 12.4 years, <italic>P</italic> < .0001). In this group, females had more frequently a chronic course and a familiarity for CH. Men with PO had some significant distinctive features, including higher frequency and longer duration of headache attacks, and higher proportion of various cranial autonomic and migraine‐like symptoms. Conclusions: We confirmed that CH with childhood onset does not show a male predominance, which was actually inverted for chronic cases. Furthermore, males with PO seem to have a specific clinical phenotype.
- Subjects
AGE factors in disease; AUTONOMIC nervous system diseases; CLUSTER headache; DIAGNOSIS; MEDICAL errors; CRANIAL nerves; PUBERTY; SEX distribution; PHENOTYPES; DISEASE duration
- Publication
Headache: The Journal of Head & Face Pain, 2018, Vol 58, Issue 3, p443
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/head.13244