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- Title
The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes.
- Authors
Tansey MJ; Tsalikian E; Beck RW; Mauras N; Buckingham BA; Weinzimer SA; Janz KF; Kollman C; Xing D; Ruedy KJ; Steffes MW; Borland TM; Singh RJ; Tamborlane WV; The Diabetes Research in Children Network (DirecNet) Study Group; Tansey, Michael J; Tsalikian, Eva; Beck, Roy W; Mauras, Nelly; Buckingham, Bruce A
- Abstract
<bold>Objective: </bold>To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes.<bold>Research Design and Methods: </bold>Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods of walking on a treadmill to a target heart rate of 140 bpm and three 5-min rest periods. Blood glucose and plasma glucagon, cortisol, growth hormone, and norepinephrine concentrations were measured before, during, and after exercise.<bold>Results: </bold>In most subjects (83%), plasma glucose concentration dropped at least 25% from baseline, and 15 (30%) subjects became hypoglycemic (< or = 60 mg/dl) or were treated for low glucose either during or immediately following the exercise session. The incidence of hypoglycemia and/or treatment for low glucose varied significantly by baseline glucose, occurring in 86 vs. 13 vs. 6% of subjects with baseline values <120, 120-180, and >180 mg/dl, respectively (P < 0.001). Exercise-induced increases in growth hormone and norepinephrine concentrations were marginally higher in subjects whose glucose dropped < or = 70 mg/dl. Treatment of hypoglycemia with 15 g of oral glucose resulted in only about a 20-mg/dl rise in glucose concentrations.<bold>Conclusions: </bold>In youth with type 1 diabetes, prolonged moderate aerobic exercise results in a consistent reduction in plasma glucose and the frequent occurrence of hypoglycemia when preexercise glucose concentrations are <120 mg/dl. Moreover, treatment with 15 g of oral glucose is often insufficient to reliably treat hypoglycemia during exercise in these youngsters.
- Publication
Diabetes Care, 2006, Vol 29, Issue 1, p20
- ISSN
0149-5992
- Publication type
journal article