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- Title
Commentary: Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light-dark cycles in mice.
- Authors
Tsuyoshi Kitajima
- Abstract
This article explores the potential effects of aripiprazole, a second-generation antipsychotic, on circadian rhythm sleep-wake disorders, specifically delayed sleep-wake phase disorder (DSWPD). The authors suggest that aripiprazole may advance the sleep phase in DSWPD and reset the locomotor rhythm of mice following a shift in the light-dark cycle. They propose that aripiprazole's action on the suprachiasmatic nucleus (SCN) may be responsible for its effects on circadian adaptation. However, more research is needed to understand the exact mechanisms and dosage requirements for treating human DSWPD. The text emphasizes the need for further investigation into the relationship between aripiprazole and the SCN, the central circadian pacemaker, and acknowledges the limitations of the study.
- Subjects
SUPRACHIASMATIC nucleus; ARIPIPRAZOLE; SYNCHRONIC order; CHRONOBIOLOGY disorders; SLOW wave sleep; SLEEP-wake cycle; NON-REM sleep
- Publication
Frontiers in Neuroscience, 2024, p1
- ISSN
1662-4548
- Publication type
Article
- DOI
10.3389/fnins.2024.1371195