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- Title
Broad Learning Enhanced <sup>1</sup>H-MRS for Early Diagnosis of Neuropsychiatric Systemic Lupus Erythematosus.
- Authors
Li, Yan; Ge, Zuhao; Zhang, Zhiyan; Shen, Zhiwei; Wang, Yukai; Zhou, Teng; Wu, Renhua
- Abstract
In this paper, we explore the potential of using the multivoxel proton magnetic resonance spectroscopy (1H-MRS) to diagnose neuropsychiatric systemic lupus erythematosus (NPSLE) with the assistance of a support vector machine broad learning system (BL-SVM). We retrospectively analysed 23 confirmed patients and 16 healthy controls, who underwent a 3.0 T magnetic resonance imaging (MRI) sequence with multivoxel 1H-MRS in our hospitals. One hundred and seventeen metabolic features were extracted from the multivoxel 1H-MRS image. Thirty-three metabolic features selected by the Mann-Whitney U test were considered to have a statistically significant difference (p < 0.05). However, the best accuracy achieved by conventional statistical methods using these 33 metabolic features was only 77%. We turned to develop a support vector machine broad learning system (BL-SVM) to quantitatively analyse the metabolic features from 1H-MRS. Although not all the individual features manifested statistics significantly, the BL-SVM could still learn to distinguish the NPSLE from the healthy controls. The area under the receiver operating characteristic curve (AUC), the sensitivity, and the specificity of our BL-SVM in predicting NPSLE were 95%, 95.8%, and 93%, respectively, by 3-fold cross-validation. We consequently conclude that the proposed system effectively and efficiently working on limited and noisy samples may brighten a noinvasive in vivo instrument for early diagnosis of NPSLE.
- Subjects
SYSTEMIC lupus erythematosus; PROTON magnetic resonance spectroscopy; EARLY diagnosis; RECEIVER operating characteristic curves; SUPPORT vector machines
- Publication
Computational & Mathematical Methods in Medicine, 2020, p1
- ISSN
1748-670X
- Publication type
Article
- DOI
10.1155/2020/8874521