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- Title
Changes in the language system as amyloid-β accumulates.
- Authors
Reinartz, Mariska; Gabel, Silvy; Schaeverbeke, Jolien; Meersmans, Karen; Adamczuk, Katarzyna; Luckett, Emma Susanne; Meyer, Steffi De; Laere, Koen Van; Sunaert, Stefan; Dupont, Patrick; Vandenberghe, Rik; De Meyer, Steffi; Van Laere, Koen
- Abstract
Language dysfunction is common in Alzheimer's disease. There is increasing interest in the preclinical or asymptomatic phase of Alzheimer's disease. Here we examined in 35 cognitively intact older adults (age range 52-78 years at baseline, 17 male) in a longitudinal study design the association between accumulation of amyloid over a 5-6-year period, measured using PET, and functional changes in the language network measured over the same time period using task-related functional MRI. In the same participants, we also determined the association between the longitudinal functional MRI changes and a cross-sectional measure of tau load as measured with 18F-AV1451 PET. As predicted, the principal change occurred in posterior temporal cortex. In the cortex surrounding the right superior temporal sulcus, the response amplitude during the associative-semantic versus visuo-perceptual task increased over time as amyloid load accumulated (Pcorrected = 0.008). In a whole-brain voxel-wise analysis, amyloid accumulation was also associated with a decrease in response amplitude in the left inferior frontal sulcus (Pcorrected = 0.009) and the right dorsomedial prefrontal cortex (Pcorrected = 0.005). In cognitively intact older adults, cross-sectional tau load was not associated with longitudinal changes in functional MRI response amplitude. Our findings confirm the central role of the neocortex surrounding the posterior superior temporal sulcus as the area of predilection within the language network in the earliest stages of Alzheimer's disease. Amyloid accumulation has an impact on cognitive brain circuitry in the asymptomatic phase of Alzheimer's disease.
- Subjects
LINGUISTIC change; TEMPORAL lobe; FUNCTIONAL magnetic resonance imaging; NEURAL circuitry; ALZHEIMER'S disease; RESEARCH; CROSS-sectional method; RESEARCH methodology; LANGUAGE &; languages; MAGNETIC resonance imaging; EVALUATION research; COMPARATIVE studies; AGING; RESEARCH funding; PEPTIDES; LONGITUDINAL method; EMISSION-computed tomography
- Publication
Brain: A Journal of Neurology, 2021, Vol 144, Issue 12, p3756
- ISSN
0006-8950
- Publication type
journal article
- DOI
10.1093/brain/awab335