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- Title
Recent Advances in the Role of Autophagy in Endocrine-Dependent Tumors.
- Authors
Komarla, Anvita; Dufresne, Suzanne; Towers, Christina G
- Abstract
Autophagy plays a complex role in several cancer types, including endocrine-dependent cancers, by fueling cellular metabolism and clearing damaged substrates. This conserved recycling process has a dual function across tumor types where it can be tumor suppressive at early stages but tumor promotional in established disease. This review highlights the controversial roles of autophagy in endocrine-dependent tumors regarding cancer initiation, tumorigenesis, metastasis, and treatment response. We summarize clinical trial results thus far and highlight the need for additional mechanistic, preclinical, and clinical studies in endocrine-dependent tumors, particularly in breast cancer and prostate cancer.
- Subjects
AUTOPHAGY; ENDOCRINE gland tumors; CELL metabolism
- Publication
Endocrine Reviews, 2023, Vol 44, Issue 4, p629
- ISSN
0163-769X
- Publication type
Article
- DOI
10.1210/endrev/bnad001