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- Title
Cisapride Accelerates Colonic Transit in Constipated Patients with Colonic Inertia.
- Authors
Krevsky, Benjamin; Maurer, Alan H.; Malmud, Leon S.; Fisher, Robert S.
- Abstract
A double-blind cross-over trial of oral cisapride 10 mg before meals and placebo was performed to determine its effects on colonic transit in patients with severe idiopathic constipation, Nine patients with <3 spontaneous bowel movements/wk were studied. After passing a tube to the cecum, 50 µCi of 111In-DTPA were instilled into the cecum and followed for 48 h using colonic transit scintigraphy. In the group as a whole, cisapride had little effect on transit. The patients were then divided into two groups based on transit: functional rectosigmoid obstruction (FRSO) and colonic inertia (CI). In the CI group, cisapride accelerated the half emptying time of the cecum and ascending colon from 2.50 to 1.21 h (<em>p</em> < 0.05). The progression of the geometric center was also faster after cisapride in CI. In FRSO, the geometric center was unchanged by cisapride except at 48 h. Cisapride thus has a prokinetic effect on colonic transit in patients with severe idiopathic constipation, colonic inertia subtype. It may be a useful agent in the treatment of this group of patients.
- Subjects
CISAPRIDE; PLACEBOS; TUBE feeding; CONSTIPATION; CECUM; COLON (Anatomy)
- Publication
American Journal of Gastroenterology (Springer Nature), 1989, Vol 84, Issue 8, p882
- ISSN
0002-9270
- Publication type
Article