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- Title
Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature.
- Authors
Aggarwal, Gaurav; Lippi, Giuseppe; Michael Henry, Brandon
- Abstract
Introduction: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown. Method: We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19. Results: A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection. Discussion: Our findings are limited by a small number of studies and sample size. Conclusion: There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.
- Subjects
COVID-19; CEREBROVASCULAR disease; STROKE patients
- Publication
International Journal of Stroke, 2020, Vol 15, Issue 4, p385
- ISSN
1747-4930
- Publication type
Article
- DOI
10.1177/1747493020921664