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- Title
Multiple Sclerosis Is Rare in Epstein-Barr Virus-Seronegative Children with Central Nervous System Inflammatory Demyelination.
- Authors
Nourbakhsh, Bardia; Cordano, Christian; Asteggiano, Carlo; Ruprecht, Klemens; Otto, Carolin; Rutatangwa, Alice; Lui, Allysa; Hart, Janace; Flanagan, Eoin P.; James, Judith A.; Waubant, Emmanuelle
- Abstract
Although Epstein-Barr virus (EBV) is hypothesized to be a prerequisite for multiple sclerosis (MS), up to 15% of children with a diagnosis of MS were reported to be EBV-seronegative. When re-evaluating 25 EBV-seronegative children out of 189 pediatric patients with a diagnosis of clinically isolated syndrome/MS, we found anti-myelin oligodendrocyte glycoprotein (MOG) antibody in 11 of 25 (44%) EBV-seronegative but only 9 of 164 (5.5%, p < 0.001) EBV-seropositive patients. After critical review, MS remained a plausible diagnosis in only 4 of 14 EBV-seronegative/MOG antibody-negative patients. In children with an MS-like presentation, EBV seronegativity should alert clinicians to consider diagnoses other than MS, especially MOG-antibody disease. ANN NEUROL 2021;89:1234-1239.
- Subjects
CENTRAL nervous system; MULTIPLE sclerosis; MEDICAL personnel; DEMYELINATION; CHILD patients; SYNOVITIS; NEUROMYELITIS optica; MULTIPLE sclerosis diagnosis; AUTOANTIBODIES; RESEARCH; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; MEMBRANE glycoproteins; COMPARATIVE studies; EPSTEIN-Barr virus diseases; CNS demyelinating autoimmune diseases; ANTIGENS; DISEASE complications
- Publication
Annals of Neurology, 2021, Vol 89, Issue 6, p1234
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.26062