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- Title
The Porous Structure of Peripheral Nerve Guidance Conduits: Features, Fabrication, and Implications for Peripheral Nerve Regeneration.
- Authors
Wan, Teng; Wang, Yi-Lin; Zhang, Feng-Shi; Zhang, Xiao-Meng; Zhang, Yi-Chong; Jiang, Hao-Ran; Zhang, Meng; Zhang, Pei-Xun
- Abstract
Porous structure is an important three-dimensional morphological feature of the peripheral nerve guidance conduit (NGC), which permits the infiltration of cells, nutrients, and molecular signals and the discharge of metabolic waste. Porous structures with precisely customized pore sizes, porosities, and connectivities are being used to construct fully permeable, semi-permeable, and asymmetric peripheral NGCs for the replacement of traditional nerve autografts in the treatment of long-segment peripheral nerve injury. In this review, the features of porous structures and the classification of NGCs based on these characteristics are discussed. Common methods for constructing 3D porous NGCs in current research are described, as well as the pore characteristics and the parameters used to tune the pores. The effects of the porous structure on the physical properties of NGCs, including biodegradation, mechanical performance, and permeability, were analyzed. Pore structure affects the biological behavior of Schwann cells, macrophages, fibroblasts, and vascular endothelial cells during peripheral nerve regeneration. The construction of ideal porous structures is a significant advancement in the regeneration of peripheral nerve tissue engineering materials. The purpose of this review is to generalize, summarize, and analyze methods for the preparation of porous NGCs and their biological functions in promoting peripheral nerve regeneration to guide the development of medical nerve repair materials.
- Subjects
NEW General Catalogue of Nebulae &; Clusters of Stars; NERVOUS system regeneration; PERIPHERAL nervous system; VASCULAR endothelial cells; PERIPHERAL nerve injuries; NERVE tissue; MORPHOLOGY
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 18, p14132
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241814132