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- Title
Peptide-Based Agents for Cancer Treatment: Current Applications and Future Directions.
- Authors
Nhàn, Nguyễn Thị Thanh; Yamada, Tohru; Yamada, Kaori H.
- Abstract
Peptide-based strategies have received an enormous amount of attention because of their specificity and applicability. Their specificity and tumor-targeting ability are applied to diagnosis and treatment for cancer patients. In this review, we will summarize recent advancements and future perspectives on peptide-based strategies for cancer treatment. The literature search was conducted to identify relevant articles for peptide-based strategies for cancer treatment. It was performed using PubMed for articles in English until June 2023. Information on clinical trials was also obtained from ClinicalTrial.gov. Given that peptide-based strategies have several advantages such as targeted delivery to the diseased area, personalized designs, relatively small sizes, and simple production process, bioactive peptides having anti-cancer activities (anti-cancer peptides or ACPs) have been tested in pre-clinical settings and clinical trials. The capability of peptides for tumor targeting is essentially useful for peptide–drug conjugates (PDCs), diagnosis, and image-guided surgery. Immunomodulation with peptide vaccines has been extensively tested in clinical trials. Despite such advantages, FDA-approved peptide agents for solid cancer are still limited. This review will provide a detailed overview of current approaches, design strategies, routes of administration, and new technological advancements. We will highlight the success and limitations of peptide-based therapies for cancer treatment.
- Subjects
UNITED States. Food &; Drug Administration; CANCER treatment; TECHNOLOGICAL innovations; COMPUTER-assisted surgery; PEPTIDES; ANTINEOPLASTIC agents
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 16, p12931
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241612931